SciENcv is a new researcher profile system for all individuals who apply for, receive or are associated with research investments from federal agencies. We highly recommend using it to create your NIH Biosketch to meet the new requirements (NOT-OD-16-080) Below are some basic recommendations for getting started using it.
To get started using SciENcv, first sign into NCBI (preferably with your eRA Commons account if you have one). In your NCBI account, look for the SciENcv box shown below and click on the link to create a new CV.

You have several options for creating a new Profile. Below is a screenshot with recommendations for starting your first profile.

Below is a screenshot of the Contribution section of the New NIH Biosketch formatted profile. Note the options to use content from My Bibliography.

For additional details see the SciENcv Help documentation.